Rochester Police arrested a woman in connection with a homicide in 2010.
Maria Valez, 55, is now charged with second-degree murder in the stabbing death of 63-year-old Donald Rose.
Valez pleaded not guilty in court Friday. Prosecutors say DNA evidence links her to the crime scene.
Donald Rose was found stabbed to death inside his Sanford Street home on February 6, 2010. Rose's family said at that time they had no idea who would want to hurt him.
The felony complaint says Valez, in a four-and-a-half hour interview with police investigators, admitted she knew Rose and she would be arrested eventually. She said she remembers Rose would not stop bleeding.
Prosecutors allege Valez stabbed Rose 23 times.
Her family says she did not do it.
"I don't know what's going on. They took her without my knowledge so I don't know what happened until today. I know she didn't do it, that is all I know. I am trying to figure out what is going on," said Valez's husband.
"I can tell you we did not have any initial suspects, but it was a case where this individual was found and on the date he was found you go on the last time he was seen to the date he was found and then we work from there to try to locate suspects," said prosecutor Liz Buckley.
Valez remains in jail without bail. She's back in court Tuesday.